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the dose of colchicine that would induce significant toxicity for an individual is unknown.

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prophylaxis with colchicine or an nsaid is recommended for up to six months after initiation of febuxostat to prevent acute flare-ups from mobilized uric acid.

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49 furthermore, livneh et al 50 have shown that colchicine can effectively prevent the complication of secondary amyloidosis in fmf patients.

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