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Some of the cholinergic regions of the brain are closely linked to heightened feelings of perception and rewardOnce againinhaled nicotine stimulates these zones and over timethis repeated stimulation can cause feelings of addiction.
Since monoamine oxidase A and B inhibitors also enhance the catecholaminergic pathwaysby a different mechanism from bupropionconcomitant use of Zyban and monoamine oxidase inhibitorsMAOIsis contraindicatedsee section 4.3as there is an increased possibility of adverse reactions from their co-administrationAt least 14 days should elapse between discontinuation of irreversible MAOIs and initiation of treatment with ZybanFor reversible MAOIsa 24 hour period is sufficient.
This medication may interfere with certain medical/laboratory testsincluding brain scan for Parkinson’s diseaseurine screening for amphetaminespossibly causing false resultsTell laboratory personnel and all your doctors you use this drug.
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Patients should be treated for 7-9 weeksIf at seven weeks no effect is seentreatment should be discontinued.
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